By Jill P. G. Urban, Robert J. Wilkins (auth.), Seisuke Tanaka M.D., Chiaki Hamanishi M.D. (eds.)
Basic study on osteoarthritis has been performed customarily from the his tological and biochemical elements of the degenerating chondrocytes, collagen fibers, and matrix proteoglycans. Undue mechanical rigidity has been proven to be the imperative consider the initiation of osteoarthritis. even supposing the precise strategy wherein mechanical tension results in the entire destruction of cartilage tissue continues to be doubtful, numerous new examine tools have enabled us to realize a deeper realizing of the method of degeneration. In October 1997, we geared up a global symposium titled "Ad vances in Osteoarthritis" in Kobe, with the most issues being up-to-date re seek, analysis, and remedy of osteoarthritis. The lawsuits of the symposium are provided right here in 5 sections: (1) Mechanical pressure and reactions of chondrocytes, similar to intracellular ion adjustments, alterations within the cytoskeleton, intracellular messenger structures, unencumber of gasoline mediators, and adjustments in electromechanical homes of cartilage; (2) practical analysis of osteoarthritis by way of MR imaging, and utilizing calpain and collagenase III as new cartilage markers; (3) therapy with a promising uncomplicated washout process and IL-1RA and MMP antagonists; (4) Cartilage fix by way of new grafting tech niques; and (5) difficulties following overall joint alternative. We truly wish that the complicated wisdom supplied during this quantity of complaints could be priceless to our readers.
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The media were collected and cell layers were washed three times with ice-cold PBS. The cells were then placed in 1 ml of PBS using a rubber policeman, sonicated for 30s at O°C, and the proteoglycan present within the media and cells was then measured by assessing the incorporation of [35 S]sulfate into the cetylpyridinium chloride (CPC) precipitable material . PKC Activity Enzyme activity was measured using a Biotrak kit (Amersham, Little Chalfont, England). This assay system is based on the PKC-catalyzed transfer of the y-phosphate group of adenosine-5'-triphosphate to a peptide that is specific for PKC.
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Rizkalla G, Reiner A, Bogoch E, et al (1992) Studies of the articular cartilage proteoglycan aggrecan in health and osteoarthritis. Evidence for molecular heterogeneity and extensive molecular changes in disease. J Clin Invest 90:2268-2277 15. Vaatainen U, Hakkinen T, Kiviranta I, et al (1995) Proteoglycan depletion and size reduction in lesions of early grade chondromalacia of the patella. Ann Rheum Dis 54:831-835 16. Sandy JD, Adams ME, Billingham MEJ, et al (1984) In vivo and in vitro stimulation of chondrocyte biosynthetic activity in early experimental osteoarthritis.
Advances in Osteoarthritis by Jill P. G. Urban, Robert J. Wilkins (auth.), Seisuke Tanaka M.D., Chiaki Hamanishi M.D. (eds.)