Get A Guide to Bone Marrow Transplantation PDF

By H. Joachim Deeg M.D., Hans-Georg Klingemann M.D., Gordon L. Phillips M.D. (auth.)

ISBN-10: 0387548319

ISBN-13: 9780387548319

ISBN-10: 3540548319

ISBN-13: 9783540548317

ISBN-10: 3642973744

ISBN-13: 9783642973741

ISBN-10: 3642973760

ISBN-13: 9783642973765

In 1988 we awarded our advisor to Bone Marrow Transplan­ tation. The reception has been enthusiastic and we have now re­ ceived a flood of severe reviews, feedback and requests to supply an replace in due time. even though numerous books on marrow transplantation have lately been released, their scope and target have ordinarily been diverse. accordingly, we've determined to organize a moment version of the consultant. Our target used to be to take care of a brief, concise textual content which by no means­ theless may include adjustments that experience happened over the last 4 or 5 years. we've got streamlined the outline of pretransplant issues, via condensing sections into one (Treatment making plans and Timing of Transplantation). This additionally facilitated the assessment of debatable symptoms for marrow transplantation, for instance in sufferers with acute myelogenous leukemia in first chemotherapy-induced remission. we've up-to-date the bankruptcy facing conditioning regimens and feature extended the part on donor choice, specifically in regard to the present point of tissue typing and the id of unrelated volunteer donors. within the bankruptcy on assortment, processing, and infusion of marrow, now we have integrated fresh advancements, for instance, using closed platforms for marrow harvesting and processing and using strong section separation of stem cells.

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Extra info for A Guide to Bone Marrow Transplantation

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Recent development of molecular techniques and their application to HLA typing have refined our ability to characterize differences between patient and donor. , the determination of restriction fragment length polymorphism (RFLP), or hybridization of patient and donor DNA with oligonucleotides of known sequence capable of annealing with the complementary sequences at previously identified highly polymorphic DNA Donor Selection 37 regions (sequence specific oligonucleotide probes, or SSOP), can identify even single base-pair difference.

52 Pretransplant Considerations Organ Toxicity Screening Patients should not have impairment of any organ system that would might jeopardize an otherwise-successful transplant. It is important to emphasize that pre-transplant impairment may be subclinical or subtle, only to become manifest after the "stress" of the conditioning regimen or transplant. Therefore, systematic evaluation of liver, kidney, lung, heart and perhaps certain endocrine gland functions should be performed. , extensive anthracycline therapy and cardiac disease).

26 Pretransplant Considerations Very importantly, a patient and any accompanying family member, possibly the potential marrow donor, can visit with patients who are undergoing or recovering from transplantation. This allows for more immediate insight into the psychological stress and other problems associated with transplantation and often helps the patient to prepare better for transplantation. In addition to the physician's expertise, discussions with nurses and other support personnel are helpful.

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A Guide to Bone Marrow Transplantation by H. Joachim Deeg M.D., Hans-Georg Klingemann M.D., Gordon L. Phillips M.D. (auth.)


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